Benzofurazan anti-amyloid compounds and methods

In general, among other things, compounds of Formula I are provided: in which R11 is selected from the group consisting of benzylamino, N-methylbenzylamino, morpholino, thiomorpholino, pyrrolidino, etc.; R13 is selected from the group consisting of 3-(1-ethanol-2-yl)phenyl, 3-(1-ol-2,2,2-trifluoroet...

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Bibliographische Detailangaben
Hauptverfasser:	Reed Mark A, Wood Thomas K, Barden Christopher J, Banfield Scott C
Format:	Patent
Sprache:	eng
Schlagworte:	BLASTING CHEMISTRY ENGINEERING ELEMENTS AND UNITS GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVEFUNCTIONING OF MACHINES OR INSTALLATIONS HEATING HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE JOINTS OR FITTINGS FOR PIPES LIGHTING MEANS FOR THERMAL INSULATION IN GENERAL MECHANICAL ENGINEERING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PIPES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING THERMAL INSULATION IN GENERAL WEAPONS
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Beschreibung
Zusammenfassung:	In general, among other things, compounds of Formula I are provided: in which R11 is selected from the group consisting of benzylamino, N-methylbenzylamino, morpholino, thiomorpholino, pyrrolidino, etc.; R13 is selected from the group consisting of 3-(1-ethanol-2-yl)phenyl, 3-(1-ol-2,2,2-trifluoroethan-2-yl)phenyl, 2-(1-ol-2,2,2-trifluoroethan-2-yl)phenyl, etc.; and R12 and R14 are each independently hydrogen or alkyl. The compounds may be used to prevent or reduce the speed of oligomerization or aggregation of amyloid proteins, such as in diseases impacted, or caused, by amyloidosis. Methods of treatment are also provided.