Pharmaceutical formulations comprising 1 - (beta-d-glucopyranosyl) - 2 -thienylmethylbenzene derivatives as inhibitors of sglt

Pharmaceutical formulations comprising 1 - (beta-d-glucopyranosyl) - 2 -thienylmethylbenzene derivatives as inhibitors of sglt

The disclosure relates to 1-( -D-glucopyranosyl)-2-thienylmethylbenzene derivatives of formula (I), wherein the variables are as defined in the specification. These compounds are suitable for treating or delaying the progression or onset of a sodium-dependent glucose transporter mediated disorder se...

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Bibliographische Detailangaben
Hauptverfasser: JOSEPH THOMAS C, WANG WENHUA, OUTWIN TODD
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The disclosure relates to 1-( -D-glucopyranosyl)-2-thienylmethylbenzene derivatives of formula (I), wherein the variables are as defined in the specification. These compounds are suitable for treating or delaying the progression or onset of a sodium-dependent glucose transporter mediated disorder selected from diabetes mellitus, diabetic retinopathy, diabetic neuropathy, diabetic nephropathy, delayed wound healing, insulin resistance, hyperglycemia, hyperinsulinemia, elevated blood levels of fatty acids, elevated blood levels of glycerol, hyperlipidemia, obesity, hypertriglyceridemia, Syndrome X, diabetic complications, atherosclerosis, or hypertension.