Cross-reactive staphylococcus aureus antibody

The subject relates to a cross-neutralizing antibody comprising at least one polyspecific binding site that binds to alpha-toxin (Hla) and at least one of the bi- component toxins of Staphylococcus aureus, its medical and diagnostic use, method of producing the antibody, including an isolated nucleo...

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Bibliographische Detailangaben
Hauptverfasser:	Visram Zehra, Jaegerhofer Michaela, Nagy Gábor, Mirkina Irina, Zerbs Manuel, Teubenbacher Astrid, Badarau Adriana, Nagy Eszter, Rouha Harald, Magyarics Zoltán, Battles Michael Benjamin, Stulik Lukas, Prinz Bianka Dominique, Dolezilkova Ivana
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The subject relates to a cross-neutralizing antibody comprising at least one polyspecific binding site that binds to alpha-toxin (Hla) and at least one of the bi- component toxins of Staphylococcus aureus, its medical and diagnostic use, method of producing the antibody, including an isolated nucleotide sequence, plasmids and host cells as used in the production of the antibody; and further an isolated conformational epitope recognized by a specific cross-neutralizing antibody.