Phenicol antibacterials
Disclosed herein are phenicol derivatives of formula I where the variables are as defined herein. Also disclosed is their use for the treatment of infections in mammals, pharmaceutical compositions containing the compounds, and methods for the preparation of these compounds. Specific examples of the...
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| creator | GOODWIN RICHARD M DUCLOS BRIAN A CURTIS MICHAEL KYNE GRAHAM M EWIN RICHARD A VAIRAGOUNDAR RAJENDRAN JOHNSON TIMOTHY A HABER-STUK ANDREA K SHEEHAN SUSAN M.K JOHNSON PAUL D BILLEN DENIS |
| description | Disclosed herein are phenicol derivatives of formula I where the variables are as defined herein. Also disclosed is their use for the treatment of infections in mammals, pharmaceutical compositions containing the compounds, and methods for the preparation of these compounds. Specific examples of the compounds of formula I are N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(methyl-sulfonamidomethyl)pyridin-3-yl)phenyl)propan-2-yl)methanesulfonamide and N-((1R,2S)-1-(4-(2-(1-aminoethyl)thiazol-5-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide. |
| format | Patent |
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Also disclosed is their use for the treatment of infections in mammals, pharmaceutical compositions containing the compounds, and methods for the preparation of these compounds. Specific examples of the compounds of formula I are N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(methyl-sulfonamidomethyl)pyridin-3-yl)phenyl)propan-2-yl)methanesulfonamide and N-((1R,2S)-1-(4-(2-(1-aminoethyl)thiazol-5-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160826&DB=EPODOC&CC=NZ&NR=630099A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25551,76304</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160826&DB=EPODOC&CC=NZ&NR=630099A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GOODWIN RICHARD M</creatorcontrib><creatorcontrib>DUCLOS BRIAN A</creatorcontrib><creatorcontrib>CURTIS MICHAEL</creatorcontrib><creatorcontrib>KYNE GRAHAM M</creatorcontrib><creatorcontrib>EWIN RICHARD A</creatorcontrib><creatorcontrib>VAIRAGOUNDAR RAJENDRAN</creatorcontrib><creatorcontrib>JOHNSON TIMOTHY A</creatorcontrib><creatorcontrib>HABER-STUK ANDREA K</creatorcontrib><creatorcontrib>SHEEHAN SUSAN M.K</creatorcontrib><creatorcontrib>JOHNSON PAUL D</creatorcontrib><creatorcontrib>BILLEN DENIS</creatorcontrib><title>Phenicol antibacterials</title><description>Disclosed herein are phenicol derivatives of formula I where the variables are as defined herein. Also disclosed is their use for the treatment of infections in mammals, pharmaceutical compositions containing the compounds, and methods for the preparation of these compounds. 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Also disclosed is their use for the treatment of infections in mammals, pharmaceutical compositions containing the compounds, and methods for the preparation of these compounds. Specific examples of the compounds of formula I are N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(methyl-sulfonamidomethyl)pyridin-3-yl)phenyl)propan-2-yl)methanesulfonamide and N-((1R,2S)-1-(4-(2-(1-aminoethyl)thiazol-5-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Phenicol antibacterials |
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