Phenicol antibacterials

Phenicol antibacterials

Disclosed herein are phenicol derivatives of formula I where the variables are as defined herein. Also disclosed is their use for the treatment of infections in mammals, pharmaceutical compositions containing the compounds, and methods for the preparation of these compounds. Specific examples of the...

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Bibliographische Detailangaben
Hauptverfasser: GOODWIN RICHARD M, DUCLOS BRIAN A, CURTIS MICHAEL, KYNE GRAHAM M, EWIN RICHARD A, VAIRAGOUNDAR RAJENDRAN, JOHNSON TIMOTHY A, HABER-STUK ANDREA K, SHEEHAN SUSAN M.K, JOHNSON PAUL D, BILLEN DENIS
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Disclosed herein are phenicol derivatives of formula I where the variables are as defined herein. Also disclosed is their use for the treatment of infections in mammals, pharmaceutical compositions containing the compounds, and methods for the preparation of these compounds. Specific examples of the compounds of formula I are N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(6-(methyl-sulfonamidomethyl)pyridin-3-yl)phenyl)propan-2-yl)methanesulfonamide and N-((1R,2S)-1-(4-(2-(1-aminoethyl)thiazol-5-yl)phenyl)-3-fluoro-1-hydroxypropan-2-yl)-2,2-difluoroacetamide.