Peptide or peptide complex binding to 2 integrin and methods and uses involving the same

Peptide or peptide complex binding to 2 integrin and methods and uses involving the same

Discloses a peptide, peptide complex or antibody wherein said peptide or peptide complex, antibody or fragment specifically binds to the I-domain of a human a2-integrin, said antibody or fragment comprising a heavy chain variable region (VB) domain and a light chain variable region (VL) domain, wher...

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Bibliographische Detailangaben
Hauptverfasser: CORVEY CARSTEN, DABDOUBI TARIK, BLUM HORST, PAPIN DAVID, CAMERON BÉATRICE, DECARY STEPHANIE, BAURIN NICOLAS, LANGE CHRISTIAN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Beschreibung
Zusammenfassung:Discloses a peptide, peptide complex or antibody wherein said peptide or peptide complex, antibody or fragment specifically binds to the I-domain of a human a2-integrin, said antibody or fragment comprising a heavy chain variable region (VB) domain and a light chain variable region (VL) domain, wherein said antibody or fragment cross-reacts with a non-human primate a2-integrin but does not cross-react with a non-primate a2-integrin. Further discloses where the antibody competes with a reference antibody for binding to the I-domain of a human a2-integrin, wherein the antibody is encoded on the plasmid deposited under DSMZ under accession No. DSM 23944, DSM 23946 or No. DSM 23945.