Gender-specific identification of sperm cells and embryos using locked nucleic acids

Gender-specific identification of sperm cells and embryos using locked nucleic acids

Disclosed are methods for gender specifically separating a population of sperm cells or non-human embryos. Said methods comprise contacting the population with a labelled locked nucleic acid capable of binding to gender-specific tandem repeat sequences in a portion of the population to provide a lab...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HRDLICKA PATRICK, VERSTEGEN JOHN, DIDION BRADLEY
Format: Patent
Sprache:eng
Schlagworte:
DIAGNOSIS
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
MEDICAL OR VETERINARY SCIENCE
SURGERY
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Beschreibung
Zusammenfassung:Disclosed are methods for gender specifically separating a population of sperm cells or non-human embryos. Said methods comprise contacting the population with a labelled locked nucleic acid capable of binding to gender-specific tandem repeat sequences in a portion of the population to provide a labelled fraction and an unlabelled fraction, then separating the labelled from the unlabelled. Also disclosed are sperm cells and non-human embryos comprising a labelled locked nucleic acid bound to a gender-specific repeat sequence