Mglu 2/3 agonists

Mglu 2/3 agonists

The present disclosure provides novel mGlu2/3 agonists of formula (I) useful in the treatment of neurological or psychiatric disorders. An example of the compound is (1S,2S,5R,6S)-2-[[(2S)-2-amino-4-methylsulfanyl-butanoyl]amino]spiro[bicyclo[3.1.0]hexane-4,1'-cyclopropane]-2,6-dicarboxylic aci...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PRIETO LOURDES, CLARK BARRY PETER, MONN JAMES ALLEN, BAKER STEPHEN RICHARD, BEADLE CHRISTOPHER DAVID
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure provides novel mGlu2/3 agonists of formula (I) useful in the treatment of neurological or psychiatric disorders. An example of the compound is (1S,2S,5R,6S)-2-[[(2S)-2-amino-4-methylsulfanyl-butanoyl]amino]spiro[bicyclo[3.1.0]hexane-4,1'-cyclopropane]-2,6-dicarboxylic acid.