Novel pyrrole derivatives

The disclosure relates to pyrrole derivative compounds of formula (I) which are cytolysin inhibitors, wherein R1, R2, R3, R4a and R4b are as defined in the specification. These compounds are suitable for use in the treatment of bacterial infections caused by bacteria selected from Streptococcus spp....

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Bibliographische Detailangaben
Hauptverfasser: ANDREW PETER WILLIAM, HAMZA DANIEL, DAMASO MAFALDA PIRES, LONNEN RANA, HIRST SIMON CHRISTOPHER, FRICKEL FRITZ-FRIEDER, DAVIES MARK WILLIAM
Format: Patent
Sprache:eng
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Zusammenfassung:The disclosure relates to pyrrole derivative compounds of formula (I) which are cytolysin inhibitors, wherein R1, R2, R3, R4a and R4b are as defined in the specification. These compounds are suitable for use in the treatment of bacterial infections caused by bacteria selected from Streptococcus spp. (e.g. Streptococcus pneumoniae, Group A Streptococci or Streptococcus suis), Clostridium spp. (e.g. Clostridium perfringens), Listeria spp. (e.g. Listeria monocytogenes) or Bacillus spp. (e.g. Bacillus anthracis) which produce pore-forming toxins, such as cholesterol dependent cytolysins. These compounds are also suitable for the treatment of conditions selected from gas gangrene, gastrointestinal anthrax, inhalational anthrax, porcine meningitis, encephalitis, septicaemia/bacteraemia and pneumonia which are caused by bacteria other than pneumococcus.