Methods for preparing anti-viral nucleotide analogs

Methods for preparing anti-viral nucleotide analogs

Disclosed herein is a method for the selective crystallisation of the diasteromer 9-{ (R)-2-[((S)-{ [(S)-1-(isopropoxycarbonyl)ethyl]amino} phenoxyphosphinyl)methoxy]propyl} adenine (also known as L-alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl],-1-methylet...

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Bibliographische Detailangaben
Hauptverfasser: COLBY DENISE A, WHITE NICOLE S, MARTINS ANDREW ANTHONY, ROBERTS BENJAMIN JAMES, SCOTT ROBERT WILLIAM
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Disclosed herein is a method for the selective crystallisation of the diasteromer 9-{ (R)-2-[((S)-{ [(S)-1-(isopropoxycarbonyl)ethyl]amino} phenoxyphosphinyl)methoxy]propyl} adenine (also known as L-alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl],-1-methylethyl ester) comprising reacting a solvent, and a base with 9-{ (R)-2-[((R,S)-{ [(S)-1-(isopropoxycarbonyl)ethyl]amino} phenoxyphosphinyl)methoxy]propyl} adenine in conditions that provide for the selective crystallization. Also disclosed are methods of preparing intermediates of the compound such as the non-stereospecific precursor 9-{ (R)-2-[((R,S)-{ [(S)-1-(isopropoxycarbonyl)ethyl]amino} phenoxyphosphinyl)methoxy]propyl} adenine.