R(+)-n-formyl-propargyl-aminoindan

Disclosed is R (+)-N-formyl-propargyl-aminoindan, and a process for preparing R(+)-N-formyl-propargyl-aminoindan comprising the steps of: e) mixing R-(+)-N-Propargyl-1-aminoindan (rasagiline) with formic acid in a first solvent such as acetic anhydride at a temperature of less than 30°C; f) evaporat...

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Bibliographische Detailangaben
Hauptverfasser:	KEISAR MICHAL, LIDOR-HADAS RAMY, SAFADI MUHAMMAD, LICHT DANIT, BAHAR ELIEZER, ZHOLKOVSKY MARINA, FRENKEL ANTON, COHEN RACHEL
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed is R (+)-N-formyl-propargyl-aminoindan, and a process for preparing R(+)-N-formyl-propargyl-aminoindan comprising the steps of: e) mixing R-(+)-N-Propargyl-1-aminoindan (rasagiline) with formic acid in a first solvent such as acetic anhydride at a temperature of less than 30°C; f) evaporating the first solvent to obtain an oil; g) dissolving the oil in a second solvent such as ethyl acetate to form a solution; and h) isolating and obtaining R(+)-N-formyl-propargylaminoindan from the solution.