Polypeptide constructs and uses thereof

Polypeptide constructs and uses thereof

Disclosed is a polypeptide construct comprising a peptide or polypeptide signalling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potenc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WILSON JR DAVID S, KORVER WOUTER, TAURA TETSUYA, TRAN STEPHEN, MIKESELL GLEN E, DOYLE ANTHONY G, POGUE SARAH L, POLLARD MATTHEW, LIN JACK TZUIAO, CLARKE ADAM
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:Disclosed is a polypeptide construct comprising a peptide or polypeptide signalling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen and wherein the peptide or polypeptide signalling ligand is selected from the group consisting of an IFN, IL-4 and IL-6.