Noribogaine salt ansolvates

Disclosed are noribogaine salt ansolvates and phosphate salt polymorphs prepared by slurrying methanol solvated forms of the salt in ethanol/water. The disclosed noribogaine salt ansolvates are more stable and less dense providing the advantage of more compact and smaller tablets than solvated polym...

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Bibliographische Detailangaben
Hauptverfasser:	GLESS RICHARD D, SCHINZER WILLIAM C
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are noribogaine salt ansolvates and phosphate salt polymorphs prepared by slurrying methanol solvated forms of the salt in ethanol/water. The disclosed noribogaine salt ansolvates are more stable and less dense providing the advantage of more compact and smaller tablets than solvated polymorphs for tableting while using the same amount of a noribogaine salt. The noribogaine salt ansolvates are useful for preparing pharmaceutical compositions for alleviating nociceptive pain in a patent.