4-piperidinyl compounds for use as tankyrase inhibitors
Disclosed are compounds of formula (I), wherein the substituents are as defined in the specification. Also disclosed are pharmaceutical compositions and combinations comprising a compound of formula (I) as well as the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signalin...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | TOURE BAKARY-BARRY CHEN CHRISTINE HIU-TUNG PALERMO MARK G DIPIETRO LUCIAN V FAN JIANME SHULTZ MICHAEL DAVID CHIN NOEL CHIN |
| description | Disclosed are compounds of formula (I), wherein the substituents are as defined in the specification. Also disclosed are pharmaceutical compositions and combinations comprising a compound of formula (I) as well as the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer. Examples of a compound of formula (I) are: 2-Chloro-6-{ 3-[4-(4-methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl} benzonitrile 2-{ 3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl} -3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_NZ620426A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>NZ620426A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_NZ620426A3</originalsourceid><addsrcrecordid>eNrjZDA30S3ILEgtykzJzKvMUUjOzy3IL81LKVZIyy9SKC1OVUgsVihJzMuuLEoEcjLzMjKTMkvyi4p5GFjTEnOKU3mhNDeDnJtriLOHbmpBfnxqcUFicmpeakm8X5SZkYGJkZmjMUEFAOe6LSU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>4-piperidinyl compounds for use as tankyrase inhibitors</title><source>esp@cenet</source><creator>TOURE BAKARY-BARRY ; CHEN CHRISTINE HIU-TUNG ; PALERMO MARK G ; DIPIETRO LUCIAN V ; FAN JIANME ; SHULTZ MICHAEL DAVID ; CHIN NOEL CHIN</creator><creatorcontrib>TOURE BAKARY-BARRY ; CHEN CHRISTINE HIU-TUNG ; PALERMO MARK G ; DIPIETRO LUCIAN V ; FAN JIANME ; SHULTZ MICHAEL DAVID ; CHIN NOEL CHIN</creatorcontrib><description>Disclosed are compounds of formula (I), wherein the substituents are as defined in the specification. Also disclosed are pharmaceutical compositions and combinations comprising a compound of formula (I) as well as the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer. Examples of a compound of formula (I) are: 2-Chloro-6-{ 3-[4-(4-methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl} benzonitrile 2-{ 3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl} -3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150828&DB=EPODOC&CC=NZ&NR=620426A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150828&DB=EPODOC&CC=NZ&NR=620426A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TOURE BAKARY-BARRY</creatorcontrib><creatorcontrib>CHEN CHRISTINE HIU-TUNG</creatorcontrib><creatorcontrib>PALERMO MARK G</creatorcontrib><creatorcontrib>DIPIETRO LUCIAN V</creatorcontrib><creatorcontrib>FAN JIANME</creatorcontrib><creatorcontrib>SHULTZ MICHAEL DAVID</creatorcontrib><creatorcontrib>CHIN NOEL CHIN</creatorcontrib><title>4-piperidinyl compounds for use as tankyrase inhibitors</title><description>Disclosed are compounds of formula (I), wherein the substituents are as defined in the specification. Also disclosed are pharmaceutical compositions and combinations comprising a compound of formula (I) as well as the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer. Examples of a compound of formula (I) are: 2-Chloro-6-{ 3-[4-(4-methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl} benzonitrile 2-{ 3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl} -3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDA30S3ILEgtykzJzKvMUUjOzy3IL81LKVZIyy9SKC1OVUgsVihJzMuuLEoEcjLzMjKTMkvyi4p5GFjTEnOKU3mhNDeDnJtriLOHbmpBfnxqcUFicmpeakm8X5SZkYGJkZmjMUEFAOe6LSU</recordid><startdate>20150828</startdate><enddate>20150828</enddate><creator>TOURE BAKARY-BARRY</creator><creator>CHEN CHRISTINE HIU-TUNG</creator><creator>PALERMO MARK G</creator><creator>DIPIETRO LUCIAN V</creator><creator>FAN JIANME</creator><creator>SHULTZ MICHAEL DAVID</creator><creator>CHIN NOEL CHIN</creator><scope>EVB</scope></search><sort><creationdate>20150828</creationdate><title>4-piperidinyl compounds for use as tankyrase inhibitors</title><author>TOURE BAKARY-BARRY ; CHEN CHRISTINE HIU-TUNG ; PALERMO MARK G ; DIPIETRO LUCIAN V ; FAN JIANME ; SHULTZ MICHAEL DAVID ; CHIN NOEL CHIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NZ620426A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>TOURE BAKARY-BARRY</creatorcontrib><creatorcontrib>CHEN CHRISTINE HIU-TUNG</creatorcontrib><creatorcontrib>PALERMO MARK G</creatorcontrib><creatorcontrib>DIPIETRO LUCIAN V</creatorcontrib><creatorcontrib>FAN JIANME</creatorcontrib><creatorcontrib>SHULTZ MICHAEL DAVID</creatorcontrib><creatorcontrib>CHIN NOEL CHIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>TOURE BAKARY-BARRY</au><au>CHEN CHRISTINE HIU-TUNG</au><au>PALERMO MARK G</au><au>DIPIETRO LUCIAN V</au><au>FAN JIANME</au><au>SHULTZ MICHAEL DAVID</au><au>CHIN NOEL CHIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>4-piperidinyl compounds for use as tankyrase inhibitors</title><date>2015-08-28</date><risdate>2015</risdate><abstract>Disclosed are compounds of formula (I), wherein the substituents are as defined in the specification. Also disclosed are pharmaceutical compositions and combinations comprising a compound of formula (I) as well as the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer. Examples of a compound of formula (I) are: 2-Chloro-6-{ 3-[4-(4-methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl} benzonitrile 2-{ 3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl} -3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_NZ620426A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | 4-piperidinyl compounds for use as tankyrase inhibitors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T07%3A12%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=TOURE%20BAKARY-BARRY&rft.date=2015-08-28&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ENZ620426A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |