4-piperidinyl compounds for use as tankyrase inhibitors

Disclosed are compounds of formula (I), wherein the substituents are as defined in the specification. Also disclosed are pharmaceutical compositions and combinations comprising a compound of formula (I) as well as the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signalin...

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Bibliographische Detailangaben
Hauptverfasser:	TOURE BAKARY-BARRY, CHEN CHRISTINE HIU-TUNG, PALERMO MARK G, DIPIETRO LUCIAN V, FAN JIANME, SHULTZ MICHAEL DAVID, CHIN NOEL CHIN
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Disclosed are compounds of formula (I), wherein the substituents are as defined in the specification. Also disclosed are pharmaceutical compositions and combinations comprising a compound of formula (I) as well as the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer. Examples of a compound of formula (I) are: 2-Chloro-6-{ 3-[4-(4-methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl} benzonitrile 2-{ 3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl} -3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one