Isoxazolines as inhibitors of fatty acid amide hydrolase

The present disclosure provides isoxazoline FAAH inhibitors of the formula (I): or pharmaceutically acceptable forms thereof, wherein each of G, Ra, Rb, Rc, and Rd are as defined herein. The present disclosure also provides pharmaceutical compositions comprising a compound of formula (I), or a pharm...

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Bibliographische Detailangaben
Hauptverfasser: GRENIER LOUIS, EVANS CATHERINE A, LEBLANC YVES, TIBBITTS THOMAS T, CHAN LAWRENCE K, CASTRO ALFREDO C, BEHNKE MARK L, GROGAN MICHAEL J, LIU TAO, SNYDER DANIEL A, PELUSO STEPHANE
Format: Patent
Sprache:eng
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Zusammenfassung:The present disclosure provides isoxazoline FAAH inhibitors of the formula (I): or pharmaceutically acceptable forms thereof, wherein each of G, Ra, Rb, Rc, and Rd are as defined herein. The present disclosure also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable form thereof, and a pharmaceutically acceptable excipient. The present disclosure also provides methods for treating an FAAH-mediated condition comprising administering a therapeutically effective amount of a compound of formula (I), or pharmaceutically acceptable form thereof, to a subject in need thereof.