Molecular diagnostic test for cancer

A method of predicting a subject's responsiveness to an anti-angiogenic therapeutic agent is diclsoed. The method comprises measuring expression levels of one or more biomarkers in a test sample of diseased tissue obtained from the subject to determine a sample expression score. The biomarkers...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	MICHIE CAROLINE, BYLESJO MAX, MCCAVIGAN ANDRENA, HARKIN DENNIS PAUL, DAVISON TIMOTHY, WINTER ANDREAS, HILL LAURA A, DEHARO STEVE, TRINDER CLAIRE, KEATING KATHERINE E, PROUTSKI VITALI, PATTERSON FIONNUALA, O'DONNELL JUDE, KENNEDY RICHARD, O'BRIEN EAMONN J, GOURLEY CHARLIE
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A method of predicting a subject's responsiveness to an anti-angiogenic therapeutic agent is diclsoed. The method comprises measuring expression levels of one or more biomarkers in a test sample of diseased tissue obtained from the subject to determine a sample expression score. The biomarkers are defined by an expression signature. The sample expression score are then compared to a threshold expression score; and the subject is classified as responsive or non-responsive, based on whether the sample expression score is above or below the threshold expression score. This method can be used to diagnose a subject as having a cancer or being susceptible to developing the cancer response to anti-angiogenic therapeutics or to determine a prognosis of a subject with cancer.