Amine derivatives as potassium channel blockers

Amine derivatives as potassium channel blockers

Provided are amine derivative compounds of the general formula (I), where the variables are as defined in the specification. Examples of the compounds include N-[cyclopropyl(4-methoxyphenyl)methyl]-3-(4-fluorophenyl)-N-(pyridin-2-ylmethyl)butanamide and 2-(4-Fluorophenylsulfonyl)-N-(2-phenylpropan-2...

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Bibliographische Detailangaben
Hauptverfasser: CROSSMAN JULIA, COLOVRAY VERONIQUE, JEANCLAUDE-ETTER ISABELLE, MOULD JORGEN, KUCHEL NATHAN, PAUL DHARAM, SINGH RAJINDER, AVERY THOMAS, DONINI CRISTINA, RIPPER JUSTIN, MOLETTE JEROME, HARVEY ANDREW, BOMBRUN AGNES, COOKE RACHEL
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided are amine derivative compounds of the general formula (I), where the variables are as defined in the specification. Examples of the compounds include N-[cyclopropyl(4-methoxyphenyl)methyl]-3-(4-fluorophenyl)-N-(pyridin-2-ylmethyl)butanamide and 2-(4-Fluorophenylsulfonyl)-N-(2-phenylpropan-2-yl)-N-(pyridine-2-ylmethyl)acetamide. The compounds are modulators of potassium (K+) channels, particularly Kv1.3 channels in T cells. The compounds may be useful in the treatment of autoimmune and inflammatory diseases such as multiple sclerosis.