Complement factor b analogs and their uses

Complement factor b analogs and their uses

Discloses a polypeptide comprising a complement factor B protein analogue, wherein the complement factor B analogue comprises a mutation of a free cysteine amino acid and is at least 90% identical to amino acids 26-764 of SEQ ID NOs: 1, 2 or 3; to amino acids 26-990 of SEQ ID NOs:22 or 23; to amino...

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Bibliographische Detailangaben
Hauptverfasser: LI BEIBEI, KALEKO MICHAEL, CHEN CHANGHUNG, WANG RUIGONG, LUO TIANCI, MILLER JEFFREY ALLEN
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Discloses a polypeptide comprising a complement factor B protein analogue, wherein the complement factor B analogue comprises a mutation of a free cysteine amino acid and is at least 90% identical to amino acids 26-764 of SEQ ID NOs: 1, 2 or 3; to amino acids 26-990 of SEQ ID NOs:22 or 23; to amino acids 26-480 of SEQ ID NO:2; or to amino acids 26-1003 of SEQ ID NO:26, wherein the sequences are as defined in the complete specification, and related methods, nucleic acids and vectors. These are used to modulate a complement pathway or for the study and/or treatment of various conditions or diseases related to a complement pathway.