Novel octahydrothienoquinoline derivative, pharmaceutical composition comprising derivative, and use of these

The disclosure relates to octahydrothienoquinoline compounds of general formula (I), wherein R1 - R7 are as defined in the specification. The disclosure also relates to pharmaceutical compositions comprising the compound. Example compounds include: 1-{ [(4aR*,6R*,8aR*)-2-amino-3-cyano-8-methyl-4H,4a...

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Bibliographische Detailangaben
Hauptverfasser:	NISHIMURA TOSHIHIRO, YOSHIDA MASAKO, UENO YASUNORI, KASAI KIYOSHI, TERANISHI HIROTAKA
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The disclosure relates to octahydrothienoquinoline compounds of general formula (I), wherein R1 - R7 are as defined in the specification. The disclosure also relates to pharmaceutical compositions comprising the compound. Example compounds include: 1-{ [(4aR,6R,8aR)-2-amino-3-cyano-8-methyl-4H,4aH,5H,6H,7H,8H,8aR,9H-thieno[3,2-g]quinolin-6-yl]carbonyl} -3-[2-(dimethylarnino)ethyl]-1-(2,2-dimethylpropyl)urea; 1-{ [(4aR,6R,8aR)-2-amino-3-cyano-8-methyl-4H,4aH,5H,6H,7H,8H,8aH,9H-thieno[3,2-g]quinolin-6-yl]carbonyl} -3-[(2S)-1-(dimethylarnino)propan-2-yl]-1-ethlylurea; 1-{ [(4aR,6R,8aR)-2-amino-3-cyano-8-methyl-4H,4aH,5H,6H,7H,8H,8aH,9H-thieno[3,2-g]quinolin-6-yl]carbonyl} -3-[2-(dimethylarnino)-2-methylpropyl]-l-propylurea; 1-{ [(4aR,6R,8aR*)-2-amino-3-cyano-8-methyl-4H,4aH,5H,6H,7H,8H,8aH,9H-thieno[3,2-g]quinolin-6-yl]carbonyl} -3-[2-(dimethylarnino)-2-ethylbutyl]-l-ethylurea.