Dendrimer scaffolds for pharmaceutical use

Disclosed are 2-(bis(2-(2-aminoethoxy)ethyl)amino acetic acid derived dendrimer compounds of the general formula (I), or salts thereof, and which include a 2-(2-aminoethoxy)ethyl-amine repeat unit; wherein the variables are as defined herein. Also disclosed is pharmaceutical composition comprising a...

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Bibliographische Detailangaben
Hauptverfasser:	TOMS STEVEN, RENDLE PHILLIP MARTIN
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS OF MACROMOLECULAR COMPOUNDS HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	Disclosed are 2-(bis(2-(2-aminoethoxy)ethyl)amino acetic acid derived dendrimer compounds of the general formula (I), or salts thereof, and which include a 2-(2-aminoethoxy)ethyl-amine repeat unit; wherein the variables are as defined herein. Also disclosed is pharmaceutical composition comprising a compound of formula (I) together with an active agent (such as anti-cancer agents, analgesic agents, anti-inflammatory agents, targeting agents, anti-malarial drugs, antibiotics including penicillins, sulfonamides, macrolides, tetracyclines, quinolones, cephalosporins, aminoglycosides and glycopeptides, and anti-viral agents) attached to, or encapsulated within, the compound of formula (I) together with suitable carriers and/or excipients.