Enantiomers of fluconazole analogues containing thieno-[2,3-d]pyrimidin-4(3h)-one moiety as antifungal agents

Enantiomers of fluconazole analogues containing thieno-[2,3-d]pyrimidin-4(3h)-one moiety as antifungal agents

The disclosure relates to enantiomeric fluconazole antifungal compounds of Formula (1a) and Formula (1b) containing a thieno-[2,3-D]pyrimidin-4(3)-one moiety and pharmaceutically acceptable salts thereof The disclosure also relates to method of preparing and isolating these compounds, the use of the...

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Hauptverfasser: RAO DEEPALI DAMODAR, CHANDAVARKAR MOHAN ANAND, NAWATHYE VIKAS VASANT, IYER RAMKRISHNAN RAMACHANDRAN, TAWTE AMIT CHANDRAKANT, CHAVAN GAJANAN JALINDAR, BORATE HANUMANT BAPURAO, SAWARGAVE SANGMESHWER PRABHAKAR, CHAVAN SUBHASH PRATAPRAO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The disclosure relates to enantiomeric fluconazole antifungal compounds of Formula (1a) and Formula (1b) containing a thieno-[2,3-D]pyrimidin-4(3)-one moiety and pharmaceutically acceptable salts thereof The disclosure also relates to method of preparing and isolating these compounds, the use of these compounds in prevention and treatment of fungal infections, and pharmaceutical preparations containing these compounds.