Compounds for treating respiratory syncytial virus infections

The disclosure relates to a family of compounds of formula (I) wherein X1, X2, R1, R2, and R3 are as defined in the specification. The disclosure further relates to a method of forming these compounds by synthetic means and chiral resolution. The disclosure also relates to the use of these compounds...

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Bibliographische Detailangaben
Hauptverfasser: PITT GARY ROBERT WILLIAM, MAYES PENELOPE ANNE, MITCHELL JEFFREY PETER, ANDERSON KELLY HELEN, DRAFFAN ALISTAIR GEORGE, LIM CHIN YU
Format: Patent
Sprache:eng
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Zusammenfassung:The disclosure relates to a family of compounds of formula (I) wherein X1, X2, R1, R2, and R3 are as defined in the specification. The disclosure further relates to a method of forming these compounds by synthetic means and chiral resolution. The disclosure also relates to the use of these compounds for treating respiratory syncytial virus (RSV) infections and diseases relating to the infection. Examples of the compounds include: (5aS)-5a-(4-chlorophenyl)-6-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-5a,6,7,8-tetrahydroimidazo[1',2':1,6]pyrido[3,4-b]pyrazin-10(5H)-one; (10aS)-10a-(4-chlorophenyl)-1-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-2,3,10,10a-tetrahydroimidazo[2,1-g][1,7]naphthyridin-5(1H)-one; (10aS)-10a-(4-fluorophenyl)-1-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-2,3,10,10a-tetrahydroimidazo[2,1-g][1,7]naphthyridin-5(1H)-one; (5aS)-5a-(4-fluorophenyl)-6-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-5a,6,7,8-tetrahydroimidazo[1',2':1,6]pyrido[3,4-b]pyrazin-10(5H)-one; (10aS)-10a-(4-fluoro-3-methylphenyl)-1-[(3-methyl-1,2-oxazol-4-yl)carbonyl]-2,3,10,10a-tetrahydroimidazo[2,1-g][1,7]naphthyridin-5(1H)-one.