Hybrid molecules containing pharmacophores of fluconazole as antifungal agents and their preparation

Hybrid molecules containing pharmacophores of fluconazole as antifungal agents and their preparation

Disclosed herein are antifungal compounds of general Formula 1, wherein the substituents are as defined in the specification, which contain fluconazole pharmacophore moieties coupled with other moieties including aryl enones and chalcones. Also disclosed are methods for preparing compounds of Formul...

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Bibliographische Detailangaben
Hauptverfasser: RAO DEEPALI DAMODAR, CHANDAVARKAR MOHAN ANAND, IYER RAMKRISHNAN RAMACHANDRAN, TAWTE AMIT CHANDRAKANT, BORATE HANUMANT BAPURAO, SAWARGAVE SANGMESHWER PRABHAKAR, CHAVAN SUBHASH PRATAPRAO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Disclosed herein are antifungal compounds of general Formula 1, wherein the substituents are as defined in the specification, which contain fluconazole pharmacophore moieties coupled with other moieties including aryl enones and chalcones. Also disclosed are methods for preparing compounds of Formula 1 and pharmaceutical preparations containing compounds of Formula 1 for prevention and treatment of fungal infections. Examples of a compound of Formula 1 are: (E)-1-(4-(2-(2,4-Difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)-3-phenylprop-2-en-1-one (E)-1-(4-(2-(2,4-Difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)pheny 1)-3-(4-methoxyphenyl)prop-2-en-1-one S-(+)-(E)-3-(4-chlorophenyl)-1-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)prop-2-en-1-one