Sustained release formulations using non-aqueous carriers

Sustained release formulations using non-aqueous carriers

The disclosure relates to a manufactured pre-mixed formulation for injection consisting essentially of a suspension of: (i) a pharmaceutically acceptable non-aqueous carrier which consists essentially of one or more triglycerides of C6-C12 fatty acids; and (ii) microspheres which consist essentially...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HOUCHIN MARY L, LEE ROBIN H, QI HONG, JENNINGS ROBERT N, COLEMAN SCOTT H, OEHRTMAN GREG
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The disclosure relates to a manufactured pre-mixed formulation for injection consisting essentially of a suspension of: (i) a pharmaceutically acceptable non-aqueous carrier which consists essentially of one or more triglycerides of C6-C12 fatty acids; and (ii) microspheres which consist essentially of a poly(lactide-co-glycolide) polymer having dispersed therein about 5% (w/w) exenatide as active pharmaceutical ingredient and about 2% (w/w) sucrose; wherein the ratio of lactide:glycolide in the polymer is about 1:1.