PROCESS FOR THE PREPARATION OF 1-ARYL-PYRAZOL-3-ONE INTERMEDIATES USEFUL IN THE SYNTHESIS OF SIGMA RECEPTORS INHIBITORS

PROCESS FOR THE PREPARATION OF 1-ARYL-PYRAZOL-3-ONE INTERMEDIATES USEFUL IN THE SYNTHESIS OF SIGMA RECEPTORS INHIBITORS

603864 Disclosed herein is a process for preparing 1-naphthyl-pyrazol-3-one intermediates of formulae VII and VIII, wherein the variables are defined in the specification , tautomers, and salts thereof, intermediates thereof, and the use of the intermediates in the preparation of sigma receptor inhi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: BERENGUER MAIMO, RAMON, ARIZA PIQUER, JAVIER, BARTRA SANMARTI, MARTI, MEDRANO RUPEREZ, JORGE, GARCIA GOMEZ, JORGE
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:603864 Disclosed herein is a process for preparing 1-naphthyl-pyrazol-3-one intermediates of formulae VII and VIII, wherein the variables are defined in the specification , tautomers, and salts thereof, intermediates thereof, and the use of the intermediates in the preparation of sigma receptor inhibitors. The process comprises coupling of a carboxylic acid with a hydrazine, optionally in the presence of a coupling agent such as a carbodiimide or benzotriazole coupling agent.