Styrenyl derivative compounds for treating ophthalmic diseases and disorders

603510 Disclosed are styrene derivatives (phenyl substituted alkene compounds) of formula A, G and E. The substituents are as disclosed in the specification. Examples of compound are: (Z)-3-(3-(2-Propoxystyryl)phenyl)propan-1-amine; (E)-3-(5-(2-Chloro-6-(methylthio)styryl)-2-methoxyphenyl)propan-1-amine; (E)-3-(3-(2-(1-methoxynaphthalen-2-yl)vinyl)phenyl)propan-1-amine; (E)-2-amino-N-(3-(2-(2,6,6-trimethylcyclohex-1-enyl)vinyl)phenyl)acetamide; (E)-3-(3-(pent-1-enyl)phenyl)propan-1-amine. Also disclosed are pharmaceutical compositions comprising a compound of formula (A), (E) or (G) and the use of a compound of formula (A), (E) or (G)in the manufacture of a medicament for treating an ophthalmic (eye) disease or disorder resulting at least in part from lipofuscin pigment accumulation in an eye of a subject