Crystalline forms and two solvated forms of 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one lactic acid salts

600887 A substantially pure crystalline hemi-pentahydrate form of 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one lactic acid salt characterized by the x-ray powder diffraction pattern that shows a characteristic maxima at 22.5 degrees, 2 theta. Also disclosed are pharmaceutical composition comprising the crystalline form and the use of the crystalline form in the manufacture of a medicament. The medicament is useful in the treatment of prostate cancer, colorectal cancer, breast cancer, multiple myeloma, pancreatic cancer, small cell carcinoma, acute myelogenous leukaemia, chronic myelogenous leukaemia, myelo-proliferative disease, non-small cell leukaemia, small cell leukaemia, chronic lymphoid leukaemia, sarcoma, melanoma, lymphoma, thyroid cancer, neuroendocrine cancer, renal cell cancer, gastric cancer, gastrointestinal stromal cancer, glioma, brain cancer, bladder cancer and cholangiocarcinoma.