Selective exosite inhibition of papp-a activity against igfbp-4

600205 Disclosed is a polypeptide comprising or consisting of SEQ ID NO:5, wherein said polypeptide is an antibody or fragment thereof capable of interacting with a PAPP-A exosite. >5EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSVITDMGRTTRYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGLRQFDYWGQGTLVTV...

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Hauptverfasser:	NIELSEN CLAUS GYRUP, MIKKELSEN JAKOB HAUGE, OXVIG CLAUS
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	600205 Disclosed is a polypeptide comprising or consisting of SEQ ID NO:5, wherein said polypeptide is an antibody or fragment thereof capable of interacting with a PAPP-A exosite. >5EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSVITDMGRTTRYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKGLRQFDYWGQGTLVTVSSGGGGSGGGGSGGGGSTDIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYHASQLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYGGNPTTFGQGTKVEIKRAAAHHHHHHGAAEQKLISEEDLNGAA