SUSTITUTED ( HETEROARYLMETHYL ) THIOHYDANTOINS AS ANTICANCER DRUGS

Disclosed herein is a thiohydantoin compound of formula (I) wherein the variables are defined in the specification, a method for the preparation thereof involving the reaction of an isothiocyanate intermediate with a nitrile intermediate which is then hydrolysed to yield a compound of formula (I) an...

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Hauptverfasser:	KOHR, SILKE, HAENDLER, BERNARD, FAUS GIMENEZ, HORTENSIA, CLEVE, ARWED, LUCKING, ULRICH, IRLBACHER, HORST
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	KOHR, SILKE HAENDLER, BERNARD FAUS GIMENEZ, HORTENSIA CLEVE, ARWED LUCKING, ULRICH IRLBACHER, HORST
description	Disclosed herein is a thiohydantoin compound of formula (I) wherein the variables are defined in the specification, a method for the preparation thereof involving the reaction of an isothiocyanate intermediate with a nitrile intermediate which is then hydrolysed to yield a compound of formula (I) and optionally reacted with the corresponding solvents and/or bases or acids to the solvates, salts and/or solvates of the salts thereof, for use in the treatment of a prostate cancer. Exemplary compounds include: 4-(3-{ [6-(1H-imidazol-1-yl)pyridin-3-yl]methyl} -4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile; 4-(4,4-dimethyl-3-{ [ 6-(2-methylmorpholin-4-yl)pyridin-3 -yl] methyl} -5-oxo-2-thioxoimidazolidin-l-yl)-2-(trifluoromethyl)benzonitrile; and 4-(3-{ [6-(2-methoxyethoxy)pyridin-3 -yl]methyl} -4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile.
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Exemplary compounds include: 4-(3-{ [6-(1H-imidazol-1-yl)pyridin-3-yl]methyl} -4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile; 4-(4,4-dimethyl-3-{ [ 6-(2-methylmorpholin-4-yl)pyridin-3 -yl] methyl} -5-oxo-2-thioxoimidazolidin-l-yl)-2-(trifluoromethyl)benzonitrile; and 4-(3-{ [6-(2-methoxyethoxy)pyridin-3 -yl]methyl} -4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20131025&DB=EPODOC&CC=NZ&NR=598643A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20131025&DB=EPODOC&CC=NZ&NR=598643A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KOHR, SILKE</creatorcontrib><creatorcontrib>HAENDLER, BERNARD</creatorcontrib><creatorcontrib>FAUS GIMENEZ, HORTENSIA</creatorcontrib><creatorcontrib>CLEVE, ARWED</creatorcontrib><creatorcontrib>LUCKING, ULRICH</creatorcontrib><creatorcontrib>IRLBACHER, HORST</creatorcontrib><title>SUSTITUTED ( HETEROARYLMETHYL ) THIOHYDANTOINS AS ANTICANCER DRUGS</title><description>Disclosed herein is a thiohydantoin compound of formula (I) wherein the variables are defined in the specification, a method for the preparation thereof involving the reaction of an isothiocyanate intermediate with a nitrile intermediate which is then hydrolysed to yield a compound of formula (I) and optionally reacted with the corresponding solvents and/or bases or acids to the solvates, salts and/or solvates of the salts thereof, for use in the treatment of a prostate cancer. 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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	SUSTITUTED ( HETEROARYLMETHYL ) THIOHYDANTOINS AS ANTICANCER DRUGS
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