INDENONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Disclosed herein is an indenone derivative of formula (1) wherein: n is 0, 1 or 2; R1 is C6-10aryl or a 5- to 10-membered heterocycle; Y is CH, N, N+(-C1-6alkyl), or N+(-O-); and X, R2 and R3 are defined in the specification; for preventing or treating a bone disease such as osteoporosis, bone growth disorder, bone fractures, periodontal disease, Paget's disease, metastatic carcinoma, and rheumatoid arthritis. Exemplary compounds include: 6-(2-morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one; 4-(6-(2-morpholinoethoxy)-I-oxo-3-phenyl-1H-inden-2-yl)benzamide; 6-(2-( dimethyl amino )ethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-l-one; tert-butyl 4-(2-(3-(3,5-difluorophenyl)-1-oxo-2-(pyridin-3-yl)-1H-inden-6-yloxy)ethyl)piperazine-l-carboxylate; 5-[2-( 4-(methylsulfonyl)piperazin-I-yl)ethoxy]-3-phenyl-2-p-toIyl-1H-inden-1-one; 3-(3,5-difluorophenyl )-6-(2-(1-(methylsulfonyl )piperidin-4-yl)ethoxy)-2-(pyridin-3-yl)-1H-inden-1-one; and 2-(3-fluoro-4-methoxyphenyl)-3-(2,4-difluorophenyl)-6-[2-(1,1-dioxothiomorpholin-4-yl)ethoxy]-1H-inden-1-one.