NITROIMIDAZOOXAZINES AND THEIR USES IN ANTI-TUBERCULAR THERAPY

598121 Disclosed herein is a compound of formula I, wherein the variables are defined in the specification, and the use thereof in the treatment of microbial infection. Embodiments of the compound include: (6S)-6-{ [2'-chloro-4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]methoxy} -2-nitro...

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Bibliographische Detailangaben
Hauptverfasser:	SUTHERLAND, HAMISH, SCOTT, KMENTOVA, IVETA, MA, ZHENKUN, THOMPSON, ANDREW, M, DENNY, WILLIAM, ALEXANDER, BLASER, ADRIAN, PALMER, BRIAN, DESMOND
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	598121 Disclosed herein is a compound of formula I, wherein the variables are defined in the specification, and the use thereof in the treatment of microbial infection. Embodiments of the compound include: (6S)-6-{ [2'-chloro-4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]methoxy} -2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, (6S)-2-nitro-6-({ 4-[4-(trifluoromethoxy)benzyl]benzyl} oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, and (6S)-2-Nitro-6-[(6-{ [4-(trifluoromethoxy)phenyl]ethynyl} -3-pyridinyl)methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine.