PROCESS FOR PRODUCING CARBOXYLIC ACID COMPOUND

Disclosed herein is a method for the preparation of compound (I) which involves glycidylation of compound (II) to produce compound (III) which is subsequently reacted with compound (IV) to form compound (V), which can then be transform into compound (I) by alkali hydrolysis or transesterification fo...

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Bibliographische Detailangaben
Hauptverfasser:	MATSUMOTO, KATSUYA, YOKOTA, KATSUYUKI, SHINAGAWA, YUKO, INOUE, TERUHIKO
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein is a method for the preparation of compound (I) which involves glycidylation of compound (II) to produce compound (III) which is subsequently reacted with compound (IV) to form compound (V), which can then be transform into compound (I) by alkali hydrolysis or transesterification followed by alkali hydrolysis wherein each compound is as follows: Compound I is 2'-((1R)-1-{ (2R)-3-[1-(4-chloro-3-fluorophenyl)-2-methylpropan-2-ylamino]-2-hydroxypropoxy} ethyl)-3-methylbiphenyl-4-carboxylic acid; Compound II is tert-butyl 3-methyl-2'-[(1R)-1-hydroxyethyl]biphenyl-4-carboxylate; Compound III is tert-butyl 3-methyl-2'-[(1R)-1-((R)-oxiranylmethoxy)ethyl]biphenyl-4-carboxylate Compound IV is 1-(4-chloro-3-fluorophenyl)-2-methylpropan-2-yl]amine; and Compound V is tert-butyl 2'-((1R)-1-[(2R)-3-[1-(4-chloro-3-fluorophenyl)-2-methylpropan-2-ylamino]-2-hydroxypropoxy]ethyl)-3-methylbiphenyl-4-carboxylate.