PURIFICATION OF 1-[2-(2,4-DIMETHYLPHENYLSULFANYL)PHENYL]PIPERAZINE
594658 Disclosed herein is a process for the manufacture of 1-[2-(2,4-dimethylphenylsulfanyl) phenyl]piperazine or a pharmaceutically acceptable salt thereof comprising the step of achieving a solution by dissolving 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-HBr salt in a solvent comprising...
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| creator | NICOLAJSEN, HENRIK, VIGAN ROCK, MICHAEL, HAROLD LOPEZ DE DIEGO, HEIDI |
| description | 594658 Disclosed herein is a process for the manufacture of 1-[2-(2,4-dimethylphenylsulfanyl) phenyl]piperazine or a pharmaceutically acceptable salt thereof comprising the step of achieving a solution by dissolving 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-HBr salt in a solvent comprising more than 65 %(v/v) isopropanol. Additionally disclosed is a process for the manufacture of 1- [2-(2,4-dimethylphenylsulfanyl) phenyl]piperazine or a pharmaceutically acceptable salt thereof comprising the step of dissolving 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-HBr isopropanol solvate, in a non-solvate forming solvent, followed by precipitation of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine-HBr. Specifically wherein the non-solvate forming solvent is selected from water, THF, xylene, benzene, methanol, ethanol, acetone and toluene, and mixtures thereof. Further disclosed is the compound which is 1-[2-(2,4-dimethylphenylsulfanyl)phenyl] piperazine-HBr isopropanol solvate which compound has XRPD reflections at approximately 6.44, 8.13, 8.77, 10.41 ( DEGREE 2?). |
| format | Patent |
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Additionally disclosed is a process for the manufacture of 1- [2-(2,4-dimethylphenylsulfanyl) phenyl]piperazine or a pharmaceutically acceptable salt thereof comprising the step of dissolving 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-HBr isopropanol solvate, in a non-solvate forming solvent, followed by precipitation of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine-HBr. Specifically wherein the non-solvate forming solvent is selected from water, THF, xylene, benzene, methanol, ethanol, acetone and toluene, and mixtures thereof. Further disclosed is the compound which is 1-[2-(2,4-dimethylphenylsulfanyl)phenyl] piperazine-HBr isopropanol solvate which compound has XRPD reflections at approximately 6.44, 8.13, 8.77, 10.41 ( DEGREE 2?).</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130222&DB=EPODOC&CC=NZ&NR=594658A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130222&DB=EPODOC&CC=NZ&NR=594658A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NICOLAJSEN, HENRIK, VIGAN</creatorcontrib><creatorcontrib>ROCK, MICHAEL, HAROLD</creatorcontrib><creatorcontrib>LOPEZ DE DIEGO, HEIDI</creatorcontrib><title>PURIFICATION OF 1-[2-(2,4-DIMETHYLPHENYLSULFANYL)PHENYL]PIPERAZINE</title><description>594658 Disclosed herein is a process for the manufacture of 1-[2-(2,4-dimethylphenylsulfanyl) phenyl]piperazine or a pharmaceutically acceptable salt thereof comprising the step of achieving a solution by dissolving 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-HBr salt in a solvent comprising more than 65 %(v/v) isopropanol. Additionally disclosed is a process for the manufacture of 1- [2-(2,4-dimethylphenylsulfanyl) phenyl]piperazine or a pharmaceutically acceptable salt thereof comprising the step of dissolving 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-HBr isopropanol solvate, in a non-solvate forming solvent, followed by precipitation of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine-HBr. Specifically wherein the non-solvate forming solvent is selected from water, THF, xylene, benzene, methanol, ethanol, acetone and toluene, and mixtures thereof. Further disclosed is the compound which is 1-[2-(2,4-dimethylphenylsulfanyl)phenyl] piperazine-HBr isopropanol solvate which compound has XRPD reflections at approximately 6.44, 8.13, 8.77, 10.41 ( DEGREE 2?).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAKCA3ydPN0dgzx9PdT8HdTMNSNNtLVMNIx0XXx9HUN8Yj0CfBw9Yv0CQ71cXME0poQbmyAZ4BrkGOUp58rDwNrWmJOcSovlOZmkHNzDXH20E0tyI9PLS5ITE7NSy2J94sytTQxM7VwNCaoAAAb7CqH</recordid><startdate>20130222</startdate><enddate>20130222</enddate><creator>NICOLAJSEN, HENRIK, VIGAN</creator><creator>ROCK, MICHAEL, HAROLD</creator><creator>LOPEZ DE DIEGO, HEIDI</creator><scope>EVB</scope></search><sort><creationdate>20130222</creationdate><title>PURIFICATION OF 1-[2-(2,4-DIMETHYLPHENYLSULFANYL)PHENYL]PIPERAZINE</title><author>NICOLAJSEN, HENRIK, VIGAN ; ROCK, MICHAEL, HAROLD ; LOPEZ DE DIEGO, HEIDI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NZ594658A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2013</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>NICOLAJSEN, HENRIK, VIGAN</creatorcontrib><creatorcontrib>ROCK, MICHAEL, HAROLD</creatorcontrib><creatorcontrib>LOPEZ DE DIEGO, HEIDI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NICOLAJSEN, HENRIK, VIGAN</au><au>ROCK, MICHAEL, HAROLD</au><au>LOPEZ DE DIEGO, HEIDI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PURIFICATION OF 1-[2-(2,4-DIMETHYLPHENYLSULFANYL)PHENYL]PIPERAZINE</title><date>2013-02-22</date><risdate>2013</risdate><abstract>594658 Disclosed herein is a process for the manufacture of 1-[2-(2,4-dimethylphenylsulfanyl) phenyl]piperazine or a pharmaceutically acceptable salt thereof comprising the step of achieving a solution by dissolving 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-HBr salt in a solvent comprising more than 65 %(v/v) isopropanol. Additionally disclosed is a process for the manufacture of 1- [2-(2,4-dimethylphenylsulfanyl) phenyl]piperazine or a pharmaceutically acceptable salt thereof comprising the step of dissolving 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-HBr isopropanol solvate, in a non-solvate forming solvent, followed by precipitation of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine-HBr. Specifically wherein the non-solvate forming solvent is selected from water, THF, xylene, benzene, methanol, ethanol, acetone and toluene, and mixtures thereof. Further disclosed is the compound which is 1-[2-(2,4-dimethylphenylsulfanyl)phenyl] piperazine-HBr isopropanol solvate which compound has XRPD reflections at approximately 6.44, 8.13, 8.77, 10.41 ( DEGREE 2?).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | PURIFICATION OF 1-[2-(2,4-DIMETHYLPHENYLSULFANYL)PHENYL]PIPERAZINE |
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