PURIFICATION OF 1-[2-(2,4-DIMETHYLPHENYLSULFANYL)PHENYL]PIPERAZINE

594658 Disclosed herein is a process for the manufacture of 1-[2-(2,4-dimethylphenylsulfanyl) phenyl]piperazine or a pharmaceutically acceptable salt thereof comprising the step of achieving a solution by dissolving 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-HBr salt in a solvent comprising more than 65 %(v/v) isopropanol. Additionally disclosed is a process for the manufacture of 1- [2-(2,4-dimethylphenylsulfanyl) phenyl]piperazine or a pharmaceutically acceptable salt thereof comprising the step of dissolving 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-HBr isopropanol solvate, in a non-solvate forming solvent, followed by precipitation of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine-HBr. Specifically wherein the non-solvate forming solvent is selected from water, THF, xylene, benzene, methanol, ethanol, acetone and toluene, and mixtures thereof. Further disclosed is the compound which is 1-[2-(2,4-dimethylphenylsulfanyl)phenyl] piperazine-HBr isopropanol solvate which compound has XRPD reflections at approximately 6.44, 8.13, 8.77, 10.41 ( DEGREE 2?).