PROCESSES FOR THE PREPARATION OF BENDAMUSTINE

PROCESSES FOR THE PREPARATION OF BENDAMUSTINE

592626 Disclosed is a process for the preparation of a Bendamustine precursor 4-{ S-Bis-(2-chloro-ethyl)-amino[-1-methyl-1H-benzoimidazo1-2-yl]-butyric acid ester of formula I or a pharmaceutically acceptable salt thereof, wherein R is a masked carboxylic acid, the process comprising the step of: re...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: PRZYUSKI, KATRIN, CHEN, JIAN, ROEMMELE, RENEE, CAROLINE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:592626 Disclosed is a process for the preparation of a Bendamustine precursor 4-{ S-Bis-(2-chloro-ethyl)-amino[-1-methyl-1H-benzoimidazo1-2-yl]-butyric acid ester of formula I or a pharmaceutically acceptable salt thereof, wherein R is a masked carboxylic acid, the process comprising the step of: reductively alkylating with chloroacetic acid or chloro acetaldehyde, a 4-(S-Amino-1-methyl-1H-benzoimidazol-2-yl)-butyric acid ester of formula II or a pharmaceutically acceptable saIt thereof.