IMPROVED DISSOLUTION STABILITY OF CALCIUM CARBONATE TABLETS

592528 Disclosed herein is a method for the preparation of a tablet comprising at least 50% w/w of calcium carbonate, the method comprising: providing a particulate composition comprising a) calcium carbonate, b) a binding sugar alcohol selected from sorbitol or isomalt, or combinations thereof c) a 5 non-binding sugar alcohol selected from mannitol, maltitol or xylitol, or combinations thereof and d) one or more pharmaceutically acceptable excipients, which is not magnesium stearate, calcium stearate or stearic acid; and compressing said composition using a tabletting machine equipped with at least one pair of punches and dies, wherein the pair of punches and die before filling 10 the die with said particulate composition is sprayed with a composition comprising a lubricant selected from magnesium stearate, calcium stearate or stearic acid or combinations thereof. Additionally disclosed are calcium carbonate tablets, for example a tablet containing: 70-75% w/w of calcium carbonate, 4-25% w/w of one or more binding sugar alcohols selected from sorbitol or isomalt or combinations thereof, 4-25% w/w of one or more non-binding sugar alcohols selected from mannitol, maltitol or xylitol, or combinations thereof, 2-10% w/w of one or more pharmaceutically acceptable excipients, wherein said excipients are not lubricants including magnesium stearate, calcium stearate, or stearic acid, 0-2% w/w of one or more flavours and/or artificial sweeteners, 0.001-0.01% w/w of magnesium stearate, calcium stearate or stearic acid with the proviso that the total amount corresponds to 100% w/w, and wherein the content of magnesium stearate, calcium stearate or stearic acid solely is present on the outermost (external) surface of the tablet.