CRYSTALLINE CARBOHYDRATE DERIVATIVE ALPHA LACOSAMINE HYDROCHLORIDE

CRYSTALLINE CARBOHYDRATE DERIVATIVE ALPHA LACOSAMINE HYDROCHLORIDE

Disclosed is alpha-Lactosamine hydrochloride, as shown in Formula 2 which contains less than 5 per cent of the beta form. Lactosamine is also known as: 4-O-beta-D-galactopyranosyl-D-glucosamine; 2-amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose; D-glucose, 2-amino-2-deoxy-4-O-beta-D-galactopyran...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DEKANY, GYULA, AGOSTON, KAROLY, ROHRIG, CHRISTOPH, H, PEREZ, IGNACIO FEGUEROA, BAJZA, ISTVAN, BOJSTRUP, MARIE, KROGER, LARS
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:Disclosed is alpha-Lactosamine hydrochloride, as shown in Formula 2 which contains less than 5 per cent of the beta form. Lactosamine is also known as: 4-O-beta-D-galactopyranosyl-D-glucosamine; 2-amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose; D-glucose, 2-amino-2-deoxy-4-O-beta-D-galactopyranosyl-; (2R,3R,4R,5R)-2-amino-3,5,6-trihydroxy-4-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hexanal. Also disclosed is the monohydrate form, a composition comprising the alpha form, a method for preparing the alpha monohydrate comprising preparing a solution comprising the anomeric mixture of lactosamine hydrochloride, water and at least one aliphatic alcohol at a temperature of 0 - 100 degrees C; and cooling the solution to cause crystallisation of á-lactosamine hydrochloride monohydrate. The anhydrous form is prepared by heating the monohydrate to a temperature between 20 - 172 DEG Celsius. The compound is used as an intermediate for organic synthesis of for example human milk oligosaccharides or in a food product or beverage or food supplement.