PREPARATION OF CONTROLLED RELEASE SKELETAL MUSCLE RELAXANT DOSAGE FORMS COMPRISING CYCLOBENZAPRINE

PREPARATION OF CONTROLLED RELEASE SKELETAL MUSCLE RELAXANT DOSAGE FORMS COMPRISING CYCLOBENZAPRINE

Disclosed is a method of preparing a pharmaceutical composition comprising: a) coating inert particles with a drug layering composition comprising cyclobenzaprine or a pharmaceutically acceptable salt, solvate, and/or ester thereof, and a pharmaceutically acceptable solvent, thereby forming immediat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GRINSTEAD, TIMOTHY, VENKATESH, GOPI, CLEVENGER, JAMES, M
Format: Patent
Sprache:eng
Schlagworte:
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
TRAPPING
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Beschreibung
Zusammenfassung:Disclosed is a method of preparing a pharmaceutical composition comprising: a) coating inert particles with a drug layering composition comprising cyclobenzaprine or a pharmaceutically acceptable salt, solvate, and/or ester thereof, and a pharmaceutically acceptable solvent, thereby forming immediate release (IR) beads; and b) coating the IR beads with an extended release (ER) coating composition comprising a pharmaceutically acceptable water-insoluble polymer, under an atmosphere having a dew point ranging from about 5-20 degrees C, thereby forming ER beads.