METHOD TO DETERMINE RESPONSIVENESS TO ANTIVIRAL THERAPY

Disclosed is a method for determining the likelihood that a subject having a viral infection of the liver will be responsive to antiviral therapy that includes stimulation of Interferon (IFN) activity comprising analysing before antiviral therapy the level of expression of at least one gene from the...

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Bibliographische Detailangaben
Hauptverfasser:	FILIPOWICZ, WITOLD, SARASIN-FILIPOWICZ, MAGDALENA, HEIM, MARKUS, DUONG, FRANCOIS H
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed is a method for determining the likelihood that a subject having a viral infection of the liver will be responsive to antiviral therapy that includes stimulation of Interferon (IFN) activity comprising analysing before antiviral therapy the level of expression of at least one gene from the following groups: i) LOC129607; RPLP0; and HERC5; (ii) HTATIP2; and IFI44L; (iii) IFI27; IFIT1; G1P2; IRF7; RSAD2; IFI44; OAS3; and IFIT2; (iv) LAMP3; HERC6; LOC286208; IFIT3; RALGPS1; PARP9; CCDC75; and CNP; (v) HIST1H2BG; HIST1H2BD; FLJ20035; PARP12; PNPT1; LGALS3BP; SAMD9; and LOC402560. The level of expression of the genes in the sample is compared to level of expression of the same genes in a control sample, wherein an increase in the level of expression of the genes in the sample from the subject before antiviral therapy relative to the level of expression of the same genes in the control sample indicates that the subject is not likely to be responsive to said antiviral therapy.