CHEMOKINE RECEPTOR MODULATORS
Disclosed are substituted tetrahydroquinolin-8-amine derivatives of Formula (I) for the treatment of a disorder associated with chemokine receptor activation. Specific examples of compounds of Formula (I) include: N-((9H-pyrido[3,4-b]indol-1-yl)methyl)-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine tet...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | CLARK, MICHAEL, P JOHNSON, TRICIA, L DOROH, BRANDON, C WISEMAN, JOHN, M NATCHUS, MICHAEL, G WILSON, LAWRENCE LOCKWOOD, MARK, A WAGNER, FLORENCE, F SKUDLAREK, JASON, W TAHIROVIC, YESIM, ALTAS |
| description | Disclosed are substituted tetrahydroquinolin-8-amine derivatives of Formula (I) for the treatment of a disorder associated with chemokine receptor activation. Specific examples of compounds of Formula (I) include: N-((9H-pyrido[3,4-b]indol-1-yl)methyl)-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine tetrahydrochloride N-((1H-indol-7-yl)methyl)-N-methyl-S,6,7,8-tetrahydroquinolin-8-amine N-(4-aminobutyl)-N-((3-phenyl-3H-1,2,3-triazol-4-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine tetrahydrochloride, and N-methyl-N-((1-(2-((pyridin-2-ylmethylamino)methyl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine. Compounds of Formula (I) are useful for treating a disorder selected from human immunodeficiency virus (HIV) infection, pestivirus infection and cancer. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_NZ587929A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>NZ587929A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_NZ587929A3</originalsourceid><addsrcrecordid>eNrjZJB19nD19ff29HNVCHJ1dg0I8Q9S8PV3CfVxBLKCeRhY0xJzilN5oTQ3g5yba4izh25qQX58anFBYnJqXmpJvF-UqYW5pZGlozFBBQDwziBd</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>CHEMOKINE RECEPTOR MODULATORS</title><source>esp@cenet</source><creator>CLARK, MICHAEL, P ; JOHNSON, TRICIA, L ; DOROH, BRANDON, C ; WISEMAN, JOHN, M ; NATCHUS, MICHAEL, G ; WILSON, LAWRENCE ; LOCKWOOD, MARK, A ; WAGNER, FLORENCE, F ; SKUDLAREK, JASON, W ; TAHIROVIC, YESIM, ALTAS</creator><creatorcontrib>CLARK, MICHAEL, P ; JOHNSON, TRICIA, L ; DOROH, BRANDON, C ; WISEMAN, JOHN, M ; NATCHUS, MICHAEL, G ; WILSON, LAWRENCE ; LOCKWOOD, MARK, A ; WAGNER, FLORENCE, F ; SKUDLAREK, JASON, W ; TAHIROVIC, YESIM, ALTAS</creatorcontrib><description>Disclosed are substituted tetrahydroquinolin-8-amine derivatives of Formula (I) for the treatment of a disorder associated with chemokine receptor activation. Specific examples of compounds of Formula (I) include: N-((9H-pyrido[3,4-b]indol-1-yl)methyl)-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine tetrahydrochloride N-((1H-indol-7-yl)methyl)-N-methyl-S,6,7,8-tetrahydroquinolin-8-amine N-(4-aminobutyl)-N-((3-phenyl-3H-1,2,3-triazol-4-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine tetrahydrochloride, and N-methyl-N-((1-(2-((pyridin-2-ylmethylamino)methyl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine. Compounds of Formula (I) are useful for treating a disorder selected from human immunodeficiency virus (HIV) infection, pestivirus infection and cancer.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121026&DB=EPODOC&CC=NZ&NR=587929A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121026&DB=EPODOC&CC=NZ&NR=587929A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CLARK, MICHAEL, P</creatorcontrib><creatorcontrib>JOHNSON, TRICIA, L</creatorcontrib><creatorcontrib>DOROH, BRANDON, C</creatorcontrib><creatorcontrib>WISEMAN, JOHN, M</creatorcontrib><creatorcontrib>NATCHUS, MICHAEL, G</creatorcontrib><creatorcontrib>WILSON, LAWRENCE</creatorcontrib><creatorcontrib>LOCKWOOD, MARK, A</creatorcontrib><creatorcontrib>WAGNER, FLORENCE, F</creatorcontrib><creatorcontrib>SKUDLAREK, JASON, W</creatorcontrib><creatorcontrib>TAHIROVIC, YESIM, ALTAS</creatorcontrib><title>CHEMOKINE RECEPTOR MODULATORS</title><description>Disclosed are substituted tetrahydroquinolin-8-amine derivatives of Formula (I) for the treatment of a disorder associated with chemokine receptor activation. Specific examples of compounds of Formula (I) include: N-((9H-pyrido[3,4-b]indol-1-yl)methyl)-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine tetrahydrochloride N-((1H-indol-7-yl)methyl)-N-methyl-S,6,7,8-tetrahydroquinolin-8-amine N-(4-aminobutyl)-N-((3-phenyl-3H-1,2,3-triazol-4-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine tetrahydrochloride, and N-methyl-N-((1-(2-((pyridin-2-ylmethylamino)methyl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine. Compounds of Formula (I) are useful for treating a disorder selected from human immunodeficiency virus (HIV) infection, pestivirus infection and cancer.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJB19nD19ff29HNVCHJ1dg0I8Q9S8PV3CfVxBLKCeRhY0xJzilN5oTQ3g5yba4izh25qQX58anFBYnJqXmpJvF-UqYW5pZGlozFBBQDwziBd</recordid><startdate>20121026</startdate><enddate>20121026</enddate><creator>CLARK, MICHAEL, P</creator><creator>JOHNSON, TRICIA, L</creator><creator>DOROH, BRANDON, C</creator><creator>WISEMAN, JOHN, M</creator><creator>NATCHUS, MICHAEL, G</creator><creator>WILSON, LAWRENCE</creator><creator>LOCKWOOD, MARK, A</creator><creator>WAGNER, FLORENCE, F</creator><creator>SKUDLAREK, JASON, W</creator><creator>TAHIROVIC, YESIM, ALTAS</creator><scope>EVB</scope></search><sort><creationdate>20121026</creationdate><title>CHEMOKINE RECEPTOR MODULATORS</title><author>CLARK, MICHAEL, P ; JOHNSON, TRICIA, L ; DOROH, BRANDON, C ; WISEMAN, JOHN, M ; NATCHUS, MICHAEL, G ; WILSON, LAWRENCE ; LOCKWOOD, MARK, A ; WAGNER, FLORENCE, F ; SKUDLAREK, JASON, W ; TAHIROVIC, YESIM, ALTAS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NZ587929A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2012</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>CLARK, MICHAEL, P</creatorcontrib><creatorcontrib>JOHNSON, TRICIA, L</creatorcontrib><creatorcontrib>DOROH, BRANDON, C</creatorcontrib><creatorcontrib>WISEMAN, JOHN, M</creatorcontrib><creatorcontrib>NATCHUS, MICHAEL, G</creatorcontrib><creatorcontrib>WILSON, LAWRENCE</creatorcontrib><creatorcontrib>LOCKWOOD, MARK, A</creatorcontrib><creatorcontrib>WAGNER, FLORENCE, F</creatorcontrib><creatorcontrib>SKUDLAREK, JASON, W</creatorcontrib><creatorcontrib>TAHIROVIC, YESIM, ALTAS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CLARK, MICHAEL, P</au><au>JOHNSON, TRICIA, L</au><au>DOROH, BRANDON, C</au><au>WISEMAN, JOHN, M</au><au>NATCHUS, MICHAEL, G</au><au>WILSON, LAWRENCE</au><au>LOCKWOOD, MARK, A</au><au>WAGNER, FLORENCE, F</au><au>SKUDLAREK, JASON, W</au><au>TAHIROVIC, YESIM, ALTAS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CHEMOKINE RECEPTOR MODULATORS</title><date>2012-10-26</date><risdate>2012</risdate><abstract>Disclosed are substituted tetrahydroquinolin-8-amine derivatives of Formula (I) for the treatment of a disorder associated with chemokine receptor activation. Specific examples of compounds of Formula (I) include: N-((9H-pyrido[3,4-b]indol-1-yl)methyl)-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine tetrahydrochloride N-((1H-indol-7-yl)methyl)-N-methyl-S,6,7,8-tetrahydroquinolin-8-amine N-(4-aminobutyl)-N-((3-phenyl-3H-1,2,3-triazol-4-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine tetrahydrochloride, and N-methyl-N-((1-(2-((pyridin-2-ylmethylamino)methyl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine. Compounds of Formula (I) are useful for treating a disorder selected from human immunodeficiency virus (HIV) infection, pestivirus infection and cancer.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_NZ587929A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | CHEMOKINE RECEPTOR MODULATORS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T14%3A19%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=CLARK,%20MICHAEL,%20P&rft.date=2012-10-26&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ENZ587929A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |