CHEMOKINE RECEPTOR MODULATORS

CHEMOKINE RECEPTOR MODULATORS

Disclosed are substituted tetrahydroquinolin-8-amine derivatives of Formula (I) for the treatment of a disorder associated with chemokine receptor activation. Specific examples of compounds of Formula (I) include: N-((9H-pyrido[3,4-b]indol-1-yl)methyl)-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine tet...

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Bibliographische Detailangaben
Hauptverfasser: CLARK, MICHAEL, P, JOHNSON, TRICIA, L, DOROH, BRANDON, C, WISEMAN, JOHN, M, NATCHUS, MICHAEL, G, WILSON, LAWRENCE, LOCKWOOD, MARK, A, WAGNER, FLORENCE, F, SKUDLAREK, JASON, W, TAHIROVIC, YESIM, ALTAS
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Disclosed are substituted tetrahydroquinolin-8-amine derivatives of Formula (I) for the treatment of a disorder associated with chemokine receptor activation. Specific examples of compounds of Formula (I) include: N-((9H-pyrido[3,4-b]indol-1-yl)methyl)-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine tetrahydrochloride N-((1H-indol-7-yl)methyl)-N-methyl-S,6,7,8-tetrahydroquinolin-8-amine N-(4-aminobutyl)-N-((3-phenyl-3H-1,2,3-triazol-4-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine tetrahydrochloride, and N-methyl-N-((1-(2-((pyridin-2-ylmethylamino)methyl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine. Compounds of Formula (I) are useful for treating a disorder selected from human immunodeficiency virus (HIV) infection, pestivirus infection and cancer.