STABILIZED SINGLE-LIQUID PHARMACEUTICAL COMPOSITION CONTAINING DOCETAXEL

Disclosed is a single-liquid pharmaceutical composition for injection containing docetaxel (formula 1) controlled in a pH range of 3.0 to 5.0, consisting of (A) docetaxel or pharmaceutically acceptable salts thereof; (B) a surfactant selected from the group consisting of polysorbate, polyoxyethylene...

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Bibliographische Detailangaben
Hauptverfasser:	JANG, SUN-WOO, CHA, BONG-JIN, WON, DONG-HAN, YOO, MOO-HI, KIM, JEONG-HOON
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed is a single-liquid pharmaceutical composition for injection containing docetaxel (formula 1) controlled in a pH range of 3.0 to 5.0, consisting of (A) docetaxel or pharmaceutically acceptable salts thereof; (B) a surfactant selected from the group consisting of polysorbate, polyoxyethylene glycol ester and polyoxyethylene castor oil derivatives; (C) an anhydrous ethanol in a concentration range of 100 to 800 mglml; and (D) a pH adjustor selected from the group consisting of citric acid, fumaric acid, lactic acid, stannic acid, succinic acid, maleic acid, acetic acid, tartaric acid, and phosphoric acid.