6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS

6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS

Disclosed is a benzoazepine compound of formula I wherein the substituents are disclosed within the specification. Examples of compounds of formula (I) are: 7-Chloro-6-(4-trifluoromethoxybenzylthio)-2,3,4,5-tetrahydro-1H-benzo[d]azepine; 6-[4-(1-Butyl-1H-pyrazol-3-yl)-benzylthio]-7-chloro-2,3,4,5-te...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: RODRIGUEZ, MICHAEL JOHN, COHEN, MICHAEL PHILIP, REINHARD, MATTHEW ROBERT, TIDWELL, MICHAEL WADE, BOYD, STEVEN ARMEN, CONWAY, RICHARD GERARD, HELLMAN, SARAH LYNNE, GALKA, CHRISTOPHER STANLEY, ROTHHAAR, ROGER RYAN, DEO, ARUNDHATI S, ZHANG, DEYI, MARTINEZ-GRAU, MARIA ANGELES, VICTOR, FRANTZ, WILLIAMS, ANDREW, CAERWYN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Disclosed is a benzoazepine compound of formula I wherein the substituents are disclosed within the specification. Examples of compounds of formula (I) are: 7-Chloro-6-(4-trifluoromethoxybenzylthio)-2,3,4,5-tetrahydro-1H-benzo[d]azepine; 6-[4-(1-Butyl-1H-pyrazol-3-yl)-benzylthio]-7-chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 7-Chloro-6-(6-cyclohexylmethylamino-pyridin-3-ylmethylthio)-2,3,4,5-tetrahydro-1H-benzo[d]azepine. Also disclosed is the use of a compound of formula I for the manufacture of a medicament for the treatment of obesity, an obsessive/compulsive disorder, depression or anxiety; and a pharmaceutical composition comprising a compound of formula (I).