PROCESS FOR THE PREPARATION OF ZOLMITRIPTAN, SALTS AND SOLVATES THEREOF

PROCESS FOR THE PREPARATION OF ZOLMITRIPTAN, SALTS AND SOLVATES THEREOF

Disclosed is a process for the preparation of zolmitriptan (I), comprising:(a) diazotization of (S)-4-(4-aminobenzyl)-1 ,3-oxazolidin-2-one, or a protected form thereof, to form a diazonium intermediate, followed by reduction of the diazonium intermediate using stannous chloride to give (S)-4-(4-hyd...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DATTA, DEBASHISH, PHATANGARE, KIRAN, POKHARKAR, KIRAN, GORE, VINAYAK G, GADAKAR, MAHESHKUMAR S
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed is a process for the preparation of zolmitriptan (I), comprising:(a) diazotization of (S)-4-(4-aminobenzyl)-1 ,3-oxazolidin-2-one, or a protected form thereof, to form a diazonium intermediate, followed by reduction of the diazonium intermediate using stannous chloride to give (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one, or a protected form thereof (b) condensation of (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one, or a protected form thereof, with 4-N,N-dimethylamino-butyraldehyde, or a protected form thereof, to form a hydrazone intermediate, or a protected form thereof; and (c) cyclisation of the resultant hydrazone intermediate to yield zolmitriptan (I) wherein none of the intermediates are isolated.