DRUG SELECTION FOR LUNG CANCER THERAPY USING ANTIBODY-BASED ARRAYS

Disclosed is an in vitro method for selecting a suitable anticancer drug for the treatment of a lung tumor, the method comprising: (a) isolating cells of the lung tumor after administration of an anticancer drug, or prior to incubation with the anticancer drug; (b) lysing the isolated cells to produce a cellular extract; (c) detecting an activation state of a plurality of signal transduction molecules in the cellular extract using an assay comprising a plurality of dilution series of capture antibodies specific for the plurality of signal transduction molecules, wherein the capture antibodies are restrained on a solid support, and wherein the plurality of signal transduction molecules comprises Her3 (ErbB3); and (d) determining whether the anticancer drug is suitable or unsuitable for the treatment of the lung tumor by comparing the activation state detected for the plurality of signal transduction molecules with a reference activation profile generated in the absence of the anticancer drug.