TRIAZOLO [1, 5-A] QUINOLINES AS ADENOSINE A3 RECEPTOR LIGANDS

TRIAZOLO [1, 5-A] QUINOLINES AS ADENOSINE A3 RECEPTOR LIGANDS

Disclosed are triazolo-quinoline compounds represented by general formula (I). An example of a compound of formula (I) is 2-(3-methoxyphenyl)-7-(morpholin-4-yl)-9-benzylamino-10-cyano-s-triazolo[1,5-a]quinoline. Also disclosed is the use of the compounds of formula (I) for treating asthma, chronic o...

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Bibliographische Detailangaben
Hauptverfasser: VARGANE SZEREDI, JUDIT, BOER, KINGA, FINET, MICHEL, URBAN SZABO, KATALIN, KAPUI, ZOLTAN, TIMARI, GEZA, MIKUS, ENDRE, SUSAN, EDIT, SZLAVIK, ZOLTAN, SZABO, TIBOR, BATORI, SANDOR
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed are triazolo-quinoline compounds represented by general formula (I). An example of a compound of formula (I) is 2-(3-methoxyphenyl)-7-(morpholin-4-yl)-9-benzylamino-10-cyano-s-triazolo[1,5-a]quinoline. Also disclosed is the use of the compounds of formula (I) for treating asthma, chronic obstructive pulmonary disease, acute respiratory distress syndrome, glaucoma, tumor, inflammatory bowel diseases, irritable bowel syndrome, allergic and inflammatory pain, rheumatoid arthritis, ischemia, hypoxia, arrhythmia of the heart, diseases of the kidney and mood diseases. Processes for making the compounds of formula (I) are also disclosed.