AN EXTENDED-RELEASE COMPOSITION COMPRISING A SOMATOSTATIN DERIVATIVE IN MICROPARTICLES

AN EXTENDED-RELEASE COMPOSITION COMPRISING A SOMATOSTATIN DERIVATIVE IN MICROPARTICLES

Disclosed is a pharmaceutical composition for extended release comprising microparticles with a polymer matrix comprising a linear and a branched polyactide-co-glycolide polymer and pasireotide pamoate as active ingredient, wherein the microparticles are produced by suspending pasireotide pamoate in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: LAMBERT, OLIVIER, RIEMENSCHNITTER, MARC, VUCENOVIC, VITOMIR
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Disclosed is a pharmaceutical composition for extended release comprising microparticles with a polymer matrix comprising a linear and a branched polyactide-co-glycolide polymer and pasireotide pamoate as active ingredient, wherein the microparticles are produced by suspending pasireotide pamoate in a polymer solution, wherein said polymer solution comprises methylene chloride and a polymer mixture of said linear and branched polyactide-co-glycolide polymer, wherein the concentration of the polymer mixture in methylene chloride is between 14.24% and 17.45% (weight polymer per weight polymer solution).