Ibandronate sodium polymorphs

Ibandronate sodium polymorphs

A crystalline form of ibandronate sodium having an X-ray powder diffraction pattern with peaks at about 5.5, 10.9, 19.3, 23.1, and 33.2, ±0.2 degrees two theta; and a process for preparing said crystalline form of ibandronate sodium is disclosed, wherein the process comprises the steps of: (a) provi...

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Bibliographische Detailangaben
Hauptverfasser: RAGHUPATI, BALAJI, ASNANI, MINAKSHI, THAIMATTAM, RAM, DEVARAKONDA, SURYA NARAYANA, VASAMSETTI, SATISH, KUMAR, MUPPIDI, VAMSI KRISHNA, RANGINENI, SRINIVASULU
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A crystalline form of ibandronate sodium having an X-ray powder diffraction pattern with peaks at about 5.5, 10.9, 19.3, 23.1, and 33.2, ±0.2 degrees two theta; and a process for preparing said crystalline form of ibandronate sodium is disclosed, wherein the process comprises the steps of: (a) providing a solution of ibandronate sodium in formic acid, optionally in a mixture with methyl tertiary-butyl ether;(b) heating the solution to temperatures of 45 Deg. C to about 65 Deg. C;(c) adding methyl tertiary-butyl ether;(d) separating a solid; and (e) converting the solid of step (d) into the crystalline form of ibandronate sodium.