Organic compounds for diagnosis and treatment of pathologies relating to the Hedgehog pathway

Organic compounds for diagnosis and treatment of pathologies relating to the Hedgehog pathway

Disclosed is a substituted piperidine or piperazine compound of formula (I) where the substituents are as disclosed in the description. Examples of compounds of formula (I) include: 6-[4-(4-Benzyl-phthalazin-1-yl)-piperazin-1-yl]-nicotinonitrile; 1-Benzyl-4-[4-(5-trifluoromethyl-pyridin-2-yl)-pipera...

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Bibliographische Detailangaben
Hauptverfasser: DAI, MIAO, LEI, JOHN, YUSUFF, NAEEM, KARKI, RAJESH, MILLER-MOSLIN, KAREN, KELLEHER, JOSEPH, HE, FENG, LLAMAS, LUIS, JAIN, RISHI KUMAR, MCEWAN, MICHAEL A, PEUKERT, STEFAN, PEREZ, LAWRENCE BLAS
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Disclosed is a substituted piperidine or piperazine compound of formula (I) where the substituents are as disclosed in the description. Examples of compounds of formula (I) include: 6-[4-(4-Benzyl-phthalazin-1-yl)-piperazin-1-yl]-nicotinonitrile; 1-Benzyl-4-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-phthalazine and 6-Benzyl-4-methyl-3-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyridazine. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for treating a pathology relating to the Hedgehog pathway.